This article is devoted to the study and comparative analysis of the metaphysical foundations of the worldview of Lev N. Tolstoy and Jiddu Krishnamurti. The author considers...

's argumentation in favour of essential invariability of the fundamental laws of nature is critically examined. It is contended that within the realist framework Poincareé's arguments lose their apodictical force. In this sense the assumption of inconstancy of even the fundamental laws of nature is methodologically legitimate.

Are the laws of nature real? Do they belong to the world or merely reflect the way we speak about it? If they are real, what sort of entity are they? This study contributes to the ongoing discussion of these questions by emphasizing the importance of a cosmological perspective on them. I argue that the evidence coming from modern evolutionary cosmology presents difficulties for certain currently fashionable philosophical accounts of laws, in particular, for the Dretske-Tooley-Armstrong theory. I defend, in light (...) of this evidence, the idea of laws as grounded in irreducible nomic properties of basic objects and examine its cosmological implications and consequences for the philosophy of modality. ;If the laws of nature are real, they must represent an integral aspect of the universe as a whole. From a cosmological point of view, these two totalities, the laws of nature and the universe, may be related. I begin by showing that a concern about the consequences of such possible relationship was an important factor in the historical rivalry between the steady-state and big bang cosmologies . ;The cosmological perspective on laws has still more striking implications in the context of the contemporary interplay between big-bang cosmology and high energy physics in the effort to understand the processes at work during the first moments of cosmic evolution. In a sense, the evolution of the physical state of the universe as a whole may have "carried" with it the evolution of certain nomic properties of matter. I contend that this poses problems for some nomic ontologies, such as the relations-between-universals theory, and favors the view of laws as grounded in causal powers of particulars. I show how the universe of causally powerful basic substances provides a natural framework for an interesting sense of modality characteristic of laws and how this illuminates the notoriously difficult problems of essential properties and natural kinds. (shrink)

The author’s studies in the philosophy of science, culminating in this book, were inspired by his previous research in the domains of classical and quantum gravity. In fact it was the need to bring some order in the family of modern classical theories of gravitation and to build up the appropriate conceptual foundations of quantum gravity , that forced the author to create his own methodological model of theory change, which he applies rather successfully to the most controversial case study, (...) the Lorentz-Einstein transition. (shrink)

For over a century, Haeckel's Gastraea theory remained a dominant theory to explain the origin of multicellular animals. According to this theory, the animal ancestor was a blastula‐like colony of uniform cells that gradually evolved cell differentiation. Today, however, genes that typically control metazoan development, cell differentiation, cell‐to‐cell adhesion, and cell‐to‐matrix adhesion are found in various unicellular relatives of the Metazoa, which suggests the origin of the genetic programs of cell differentiation and adhesion in the root of the Opisthokonta. Multicellular (...) stages occurring in the complex life cycles of opisthokont protists (mesomycetozoeans and choanoflagellates) never resemble a blastula. Here, we discuss a more realistic scenario of transition to multicellularity through integration of pre‐existing transient cell types into the body of an early metazoon, which possessed a complex life cycle with a differentiated sedentary filter‐feeding trophic stage and a non‐feeding blastula‐like larva, the synzoospore. Choanoflagellates are considered as forms with secondarily simplified life cycles. (shrink)

A common belief is that evolution generally proceeds towards greater complexity at both the organismal and the genomic level, numerous examples of reductive evolution of parasites and symbionts notwithstanding. However, recent evolutionary reconstructions challenge this notion. Two notable examples are the reconstruction of the complex archaeal ancestor and the intron‐rich ancestor of eukaryotes. In both cases, evolution in most of the lineages was apparently dominated by extensive loss of genes and introns, respectively. These and many other cases of reductive evolution (...) are consistent with a general model composed of two distinct evolutionary phases: the short, explosive, innovation phase that leads to an abrupt increase in genome complexity, followed by a much longer reductive phase, which encompasses either a neutral ratchet of genetic material loss or adaptive genome streamlining. Quantitatively, the evolution of genomes appears to be dominated by reduction and simplification, punctuated by episodes of complexification. (shrink)

Scale-free network models describe many natural and social phenomena. In particular, networks of interacting components of a living cell were shown to possess scale-free properties. A recent study(1) compares the system-level properties of metabolic and information networks in 43 archaeal, bacterial and eukaryal species and claims that the scale-free organization of these networks is more conserved during evolution than their content. BioEssays 24:105–109, 2002. Published 2002 Wiley Periodicals, Inc.

Malignant cells are characterized by an increased content of endogenous formaldehyde formed as a by‐product of biosynthetic processes. Accumulation of formaldehyde in cancer cells is combined with activation of the processes of cellular formaldehyde clearance. These mechanisms include increased ALDH and suppressed ADH5/FDH activity, which oncologists consider poor and favorable prognostic markers, respectively. Here, the sources and regulation of formaldehyde metabolism in cancer cells are reviewed. The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI‐1, and (...) MUC1‐C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell. The authors hypothesize that the study of the anticancer properties of disulfiram and alpha lipoic acid – which affect the balance of formaldehyde in the body – may serve as the basis of future anticancer therapy. (shrink)

O objetivo deste artigo é apontar e analisar os principais fatores que levaram uma pessoa, ou um grupo de pessoas, a assistir um jogo de futebol da Copa do Mundo 2014 em uma FIFA Fan Fest e não em outros locais. Socialização, afetividade e diversão são aspectos considerados na análise. O papel do esporte enquanto produto de entretenimento e consumo também foi contemplado no estudo. O evento, pela proliferação de imagens que proporciona, é exemplo claro do que Guy Debord definiu (...) como Sociedade do Espetáculo. Foram entrevistadas 79 pessoas em duas FIFA Fan Fests realizadas na cidade de São Paulo, em partidas da seleção brasileira na Copa do Mundo 2014. Os resultados obtidos no estudo comprovam a inserção do esporte mais popular do planeta na lógica das modernas estratégias de consumo. Também evidenciam as relações existentes entre o futebol, e seu universo, e a chamada indústria do entretenimento. (shrink)

Background Studying global health problems requires international multidisciplinary teams. Such multidisciplinarity and multiculturalism create challenges in adhering to a set of ethical principles across different country contexts. Our group on health system responses to violence against women (VAW) included two universities in a European high-income country (HIC) and four universities in low-and middle-income countries (LMICs). This study aimed to investigate professional and policy perspectives on the types, causes of, and solutions to ethical challenges specific to the ethics approval stage of (...) the global research projects on health system responses to VAW. Methods We used the Network of Ethical Relationships model, framework method, and READ approach to analyse qualitative semi-structured interviews (n = 18) and policy documents (n = 27). In March-July 2021, we recruited a purposive sample of researchers and members of Research Ethics Committees (RECs) from the five partner countries. Interviewees signposted policies and guidelines on research ethics, including VAW. Results We developed three themes with eight subthemes summarising ethical challenges across three contextual factors. The global nature of the group contributed towards power and resource imbalance between HIC and LMICs and differing RECs’ rules. Location of the primary studies within health services highlighted differing rules between university RECs and health authorities. There were diverse conceptualisations of VAW and vulnerability of research participants between countries and limited methodological and topic expertise in some LMIC RECs. These factors threatened the timely delivery of studies and had a negative impact on researchers and their relationships with RECs and HIC funders. Most researchers felt frustrated and demotivated by the bureaucratised, uncoordinated, and lengthy approval process. Participants suggested redistributing power and resources between HICs and LMICs, involving LMIC representatives in developing funding agendas, better coordination between RECs and health authorities and capacity strengthening on ethics in VAW research. Conclusions The process of ethics approval for global research on health system responses to VAW should be more coordinated across partners, with equal power distribution between HICs and LMICs, researchers and RECs. While some of these objectives can be achieved through education for RECs and researchers, the power imbalance and differing rules should be addressed at the institutional, national, and international levels. Three of the authors were also research participants, which had potential to introduce bias into the findings. However, rigorous reflexivity practices mitigated against this. This insider perspective was also a strength, as it allowed us to access and contribute to more nuanced understandings to enhance the credibility of the findings. It also helped to mitigate against unequal power dynamics. (shrink)

Background and assumptions. Persistence and philosophy of time ; Atomism and composition ; Scope ; Some matters of methodology -- Persistence, location, and multilocation in spacetime. Endurance, perdurance, exdurance : some pictures ; More pictures ; Temporal modification and the "problem of temporary intrinsics" ; Persistence, location and multilocation in generic spacetime ; An alternative classification -- Classical and relativistic spacetime. Newtonian spacetime ; Neo-Newtonian (Galilean) spacetime ; Reference frames and coordinate systems ; Galilean transformations in spacetime ; Special relativistic (...) spacetime ; Length contraction and time dilation ; Invariant properties of special relativistic spacetime -- Persisting objects in classical spacetime. Enduring, perduring, and exduring objects in Galilean spacetime ; The argument from vagueness ; From minimal D-fusions to temporal parts ; Motivating a sharp cutoff ; Some objections and replies ; Implications -- Persisting objects in Minkowski spacetime. Enduring, perduring, and exduring objects in Minkowski spacetime ; Flat and curved achronal regions in Minkowski spacetime ; Early reflections on persisting objects in Minkowski spacetime : Quine and Smart ; "Profligate ontology"? ; Is achronal universalism tenable in Minkowski spacetime? ; "Crisscrossing" and immanent causation -- Coexistence in spacetime. The notion of coexistence ; Desiderata ; Coexistence in Galilean spacetime ; Coexistence in Minkowski spacetime : CASH ; Alexandrov-Stein present and Alexandrov-Stein coexistence ; AS-Coexistence v. CASH : symmetry, multigrade, and objectivity ; As-coexistence v. CASH : relevance ; The mixed past of coexistence ; No need in the extended now -- Strange coexistence? Coexistence and existence@ ; The asymmetry thesis ; The absurdity thesis ; Collective CASH value of coexistence ; Collective existence@ and coexistence in classical spacetime ; Collective existence@ and coexistence in Minkowski spacetime ; Contextuality ; Chronological incoherence ; Some objections -- Shapes and other arrangements in Minkowski spacetime. How rigid is a granite block? ; Perspectives in space ; Perspectives in spacetime ; Are shapes intrinsic to objects? ; The causal objection ; The micro-reductive objection ; Pegs, boards, and shapes ; Perduring objects exist. (shrink)

Properties of non‐canonical GC base pairs and their relations with mechanochemical cleavage of DNA are analyzed. A hypothesis of the involvement of the transient GC wobble base pairs both in the mechanisms of the mechanochemical cleavage of DNA and epigenetic mechanisms involving of 5‐methylcytosine, is proposed. The hypothesis explains the increase in the frequency of the breaks of the sugar‐phosphate backbone of DNA after cytosines, the asymmetric character of these breaks, and an increase in break frequency in CpG after cytosine (...) methylation. As an alternative hypothesis, probable implication of GC+ Hoogsteen base pairs is considered, which now exemplify the best‐studied non‐canonical GC base pairs in the DNA double helix. Also see the video abstract here https://youtu.be/EUunVWL0ptw. (shrink)

This article traces disagreements about the genetic effects of low-dose radiation exposure as waged by James Neel, a central figure in radiation studies of Japanese populations after World War II, and Yuri Dubrova, who analyzed the 1986 Chernobyl nuclear power plant accident. In a 1996 article in Nature, Dubrova reported a statistically significant increase in the minisatellite DNA mutation rate in the children of parents who received a high dose of radiation from the Chernobyl accident, contradicting studies that found (...) no significant inherited genetic effects among offspring of Japanese A-bomb survivors. Neel’s subsequent defense of his large-scale longitudinal studies of the genetic effects of ionizing radiation consolidated current scientific understandings of low-dose ionizing radiation. The article seeks to explain how the Hiroshima/nagasaki data remain hegemonic in radiation studies, contextualizing the debate with attention to the perceived inferiority of Soviet genetic science during the Cold War. (shrink)

This chapter explores the relationship between knowing-how and skill, as well other success-in-action notions like dispositions and abilities. I offer a new view of knowledge-how which combines elements of both intellectualism and Ryleanism. According to this view, knowing how to perform an action is both a kind of knowing-that (in accord with intellectualism) and a complex multi-track dispositional state (in accord with Ryle’s view of knowing-how). I argue that this new view—what I call practical attitude intellectualism—offers an attractive set of (...) solutions to various puzzles concerning the connections between knowing-how and abilities and skills to perform intentional actions. (shrink)

The series is devoted to the study of scientific and philosophical texts from the Classical and the Islamic world handed down in Arabic. Through critical text editions and monographs, it provides access to ancient scientific inquiry as it developed in a continuous tradition from Antiquity to the modern period. All editions are accompanied by translations and philological and explanatory notes.

How should intellectualists respond to apparent Gettier-style counterexamples? Stanley offers an orthodox response which rejects the claim that the subjects in such scenarios possess knowledge-how. I argue that intellectualists should embrace a revisionary response according to which knowledge-how is a distinctively practical species of knowledge-that that is compatible with Gettier-style luck.

It is often said that ‘what it is like’-knowledge cannot be acquired by consulting testimony or reading books [Lewis 1998; Paul 2014; 2015a]. However, people also routinely consult books like What It Is Like to Go to War [Marlantes 2014], and countless ‘what it is like’ articles and youtube videos, in the apparent hope of gaining knowledge about what it is like to have experiences they have not had themselves. This article examines this puzzle and tries to solve it by (...) appealing to recent work on knowing-wh ascriptions. In closing I indicate the wider significance of these ideas by showing how they can help us to evaluate prominent arguments by Paul [2014; 2015a] concerning transformative experiences. (shrink)

This article examines the method of reflective equilibrium (RE) and its role in philosophical inquiry. It begins with an overview of RE before discussing some of the subtleties involved in its interpretation, including challenges to the standard assumption that RE is a form of coherentism. It then evaluates some of the main objections to RE, in particular, the criticism that this method generates unreasonable beliefs. It concludes by considering how RE relates to recent debates about the role of intuitions in (...) philosophy. (shrink)

In this paper I develop three different arguments against the thesis that knowledge-how is a kind of knowledge-that. Knowledge-that is widely thought to be subject to an anti-luck condition, a justified or warranted belief condition, and a belief condition, respectively. The arguments I give suggest that if either of these standard assumptions is correct then knowledge-how is not a kind of knowledge-that. In closing I identify a possible alternative to the standard Rylean and intellectualist accounts of knowledge-how. This alternative view (...) illustrates that even if the arguments given here succeed it might still be reasonable to hold that knowing how to do something is a matter of standing in an intentional relation to a proposition other than the knowledge-that relation. (shrink)

Is there a successful regress argument against intellectualism? In this article I defend the negative answer. I begin by defending Stanley and Williamson's (2001) critique of the contemplation regress against Noë (2005). I then identify a new argument – the employment regress – that is designed to succeed where the contemplation regress fails, and which I take to be the most basic and plausible form of a regress argument against intellectualism. However, I argue that the employment regress still fails. Drawing (...) on the previous discussion, I criticise further regress arguments given by Hetherington (2006) and Noë (2005). (shrink)

Knowledge-how often appears to be more difficult to transmit by testimony than knowledge-that and knowledge-wh. Some philosophers have argued that this difference provides us with an important objection to intellectualism—the view that knowledge-how is a species of knowledge-that. This article defends intellectualism against these testimony-based objections.

Paul (2014, 2015a) argues that one cannot rationally decide whether to have a transformative experience by trying to form judgments, in advance, about (i) what it would feel like to have that experience, and (ii) the subjective value of having such an experience. The problem is if you haven’t had the experience then you cannot know what it is like, and you need to know what it is like to assess its value. However, in earlier work I argued that ‘what (...) it is like’-knowledge comes in degrees, and I briefly suggested that, consequently, some instances of Paul’s argument schema might commit a fallacy of equivocation. The aim of this paper is to further explore and strengthen this objection by, first, offering a new argument—the modelling argument—in support of it, and then by evaluating a range of replies that might be given to this objection on Paul’s behalf. I conclude that each reply either fails or, at best, only partially succeeds in defending some but not all instances of Paul’s argument schema. In closing, I consider how we might revise Paul’s concepts of transformative experiences and choices in response to this conclusion. (shrink)

What is the relationship between the linguistic properties of knowledge-how ascriptions and the nature of knowledge-how itself? In this chapter I address this question by examining the linguistic methodology of Stanley and Williamson (2011) and Stanley (2011a, 2011b) who defend the intellectualist view that knowledge-how is a kind of knowledge-that. My evaluation of this methodology is mixed. On the one hand, I defend Stanley and Williamson (2011) against critics who argue that the linguistic premises they appeal to—about the syntax and (...) semantics of knowledge-how and knowledge-wh ascriptions—do not establish their desired conclusions about the nature of knowledge-how itself. But, on the other hand, I also criticize the role that linguistic considerations play in Stanley’s (2011a) response to apparent Gettier-style counterexamples to intellectualism. (shrink)

What follows for the ability hypothesis reply to the knowledge argument if knowledge-how is just a form of knowledge-that? The obvious answer is that the ability hypothesis is false. For the ability hypothesis says that, when Mary sees red for the first time, Frank Jackson’s super-scientist gains only knowledge-how and not knowledge-that. In this paper I argue that this obvious answer is wrong: a version of the ability hypothesis might be true even if knowledge-how is a form of knowledge-that. To (...) establish this conclusion I utilize Jason Stanley and Timothy Williamson’s well-known account of knowledge-how as “simply a species of propositional knowledge” . I demonstrate that we can restate the core claims of the ability hypothesis – that Mary only gains new knowledge-how and not knowledge-that – within their account of knowledge-how as a species of knowledge-that. I examine the implications of this result for both critics and proponents of the ability hypothesis. (shrink)

Yuri Balashov sets out major rival views of persistence--endurance, perdurance, and exdurance--in a spacetime framework and proceeds to investigate the implications of Einstein's theory of relativity for the debate about persistence. His overall conclusion--that relativistic considerations favour four-dimensionalism over three-dimensionalism--is hardly surprising. It is, however, anything but trivial. Contrary to a common misconception, there is no straightforward argument from relativity to four-dimensionalism. The issues involved are complex, and the debate is closely entangled with a number of other philosophical disputes, (...) including those about the nature and ontology of time, parts and wholes, material constitution, causation and properties, and vagueness. (shrink)

In this paper, the ethical, legal, and social implications of Thailand’s surrogacy regulations from both domestic and global perspectives are explored. Surrogacy tourism in Thailand has expanded since India strengthened its visa regulations in 2012. In 2015, in the wake of a major scandal surrounding the abandonment of a surrogate child by its foreign intended parents, a law prohibiting the practice of surrogacy for commercial purposes was enacted. Consequently, a complete ban on surrogacy tourism was imposed. However, some Thai physicians (...) and surrogate mothers cross into neighboring countries to provide foreign clients with the commercial surrogacy services that are forbidden in Thailand. Under this legislation, the needs of Thai couples who are unable to conceive are accommodated by legally accessible, non-commercial surrogacy services; however, there is currently no provision in place aimed at protecting the rights and interests of surrogate mothers and children. It is widely believed that the abolition of surrogacy tourism, an industry that give rise to several major scandals, and legal access to surrogacy by Thai couples were the Thai government’s primary goal in implementing this legislation. (shrink)

Many philosophers accept a view – what I will call the intuition picture – according to which intuitions are crucial evidence in philosophy. Recently, Williamson has argued that such views are best abandoned because they lead to a psychologistic conception of philosophical evidence that encourages scepticism about the armchair judgements relied upon in philosophy. In this paper I respond to this criticism by showing how the intuition picture can be formulated in such a way that: it is consistent with a (...) wide range of views about not only philosophical evidence but also the nature of evidence in general, including Williamson's famous view that E = K; it can maintain the central claims about the nature and role of intuitions in philosophy made by proponents of the intuition picture; it does not collapse into Williamson's own deflationary view of the nature and role of intuitions in philosophy; and it does not lead to scepticism. (shrink)

This chapter examines some key developments in discussions of the social dimensions of knowing-how, focusing on work on the social function of the concept of knowing-how, testimony, demonstrating one's knowledge to other people, and epistemic injustice. I show how a conception of knowing-how as a form of 'downstream knowledge' can help to unify various phenomena discussed within this literature, and I also consider how these ideas might connect with issues concerning wisdom, moral knowledge, and moral testimony.

Background In an increasingly globalized world, legal protocols related to health care that are both effective and culturally sensitive are paramount in providing excellent quality of care as well as protection for physicians tasked with decision making. Here, we analyze the current medicolegal status of brain death diagnosis with regard to end-of-life care in Japan, China, and South Korea from the perspectives of front-line health care workers. Main body Japan has legally wrestled with the concept of brain death for decades. (...) An inability to declare brain death without consent from family coupled with cultural expectations of family involvement in medical care is mirrored in other Confucian-based cultures and may complicate care for patients from these countries when traveling or working overseas. Within Japan, China, and South Korea, medicolegal shortcomings in the diagnosis of brain death act as a great source of stress for physicians and expose them to potential public and legal scorn. Here, we detail the medicolegal status of brain death diagnosis within Japan and compare it to China and South Korea to find common ground and elucidate the impact of legal ambiguity on health care workers. Conclusion The Confucian cultural foundation of multiple Asian countries raises common issues of family involvement with diagnosis and cultural considerations that must be met. Leveraging public education systems may increase awareness of brain death issues and lead to evolving laws that clarify such end-of-life issues while protecting physicians from sociocultural backlash. (shrink)

Hawley introduced the idea of the client's perspective on knowledge, which she used to illuminate knowing-how and cases of epistemic injustice involving knowing-how. In this paper, I explore how Hawley's idea might be used to illuminate not only knowing-how, but other forms of knowledge that, like knowing-how, are often claimed to be distinct from mere knowing-that, focusing on the case studies of moral understanding and ‘what it is like’-knowledge.

I examine the issue of persistence over time in thecontext of the special theory of relativity (SR). Thefour-dimensional ontology of perduring objects isclearly favored by SR. But it is a different questionif and to what extent this ontology is required, andthe rival endurantist ontology ruled out, by thistheory. In addressing this question, I take theessential idea of endurantism, that objects are whollypresent at single moments of time, and argue that itcommits one to unacceptable conclusions regardingcoexistence, in the context of SR. (...) I then propose anddiscuss a plausible account of coexistence forperduring objects, which is free of these defects. This leaves the endurantist room for some maneuvers. I consider them and show that they do not really helpthe endurantist out. She can accommodate the notionof coexistence in the relativistic framework only atthe cost of renouncing central endurantist intuitions. (shrink)

Although considerations based on contemporary space-time theories, such as special and general relativity, seem highly relevant to the debate about persistence, their significance has not been duly appreciated. My goal in this paper is twofold: (1) to reformulate the rival positions in the debate (i.e., endurantism [three-dimensionalism] and perdurantism [four-dimensionalism, the doctrine of temporal parts]) in the framework of special relativistic space-time; and (2) to argue that, when so reformulated, perdurantism exhibits explanatory advantages over endurantism. The argument builds on the (...) fact that four-dimensional entities extended in space as well as time are relativistically invariant in a way three-dimensional entities are not. (shrink)

Previous work suggests that Asians allocate more attention to configuration information than Caucasian Americans do. Yet this cultural variation has been found only with stimuli such as natural scenes and objects that require both feature- and configuration-based processing. Here, we show that the cultural variation also exists in face perception—a domain that is typically viewed as configural in nature. When asked to identify a prototypic face for a set of disparate exemplars, Japanese were more likely than Caucasian Americans to use (...) overall resemblance rather than feature matching. Moreover, in a speeded identity-matching task, Japanese were more accurate than Americans in identifying the spatial configuration of features (e.g., eyes). Together, these findings underscore the robustness of culture’s influences on cognition. (shrink)

Surrogacy tourism in Asian countries has surged in recent decades due to affordable prices and favourable regulations. Although it has recently been banned in many countries, it is still carried out illegally across borders. With demand for surrogacy in developed countries increasing and economically vulnerable Asian women lured by lucrative compensation, there are efforts by guest countries to ease the strict surrogacy regulations in host countries. Despite a shift toward “altruistic surrogacy”, commercial surrogacy persists. Recent research carried out by international (...) organizations that seek to establish a legal relationship between the commissioning parents and children in cross-border surrogacy arrangements, under the guise of the “best interests of the child,” appears to promote a resurgence of overseas commercial surrogacy rather than restrict it. Further commercialization of surrogacy should be prevented by carefully investigating the reality of the surrogacy process. (shrink)